2019-2020

ARTICLE: Disentanglement of the chemical, physical, and biological processes aids the development of quantitative structure-biodegradation relationships for aerobic wastewater treatment Nolte TM, Guangchao C, van Schayk CS, Pinto-Gil K, Hendriks AJ, Peijnenburg W, Ragas A. Sci Total Environ (2020): 708. 133863. Partner: RU (March 2020)

ARTICLE: Combined ion-trapping and mass balance models to describe the pH‐Dependent uptake and toxicity of acidic and basic pharmaceuticals in zebrafish embryos (danio rerio) Bittner L, Klüver N, Henneberger L, Mühlenbrink M, Zarfl C, Escher B. Environ Sci Technol. (2019). Partner: UFZ (June 2019)

ARTICLE: Pharmacology beyond the patient – The environmental risks of human drugs. Gunnarsson L, Snape J, Verbruggen B, Owen S, Kristiansson E, Margiotta-Casaluci L, Österlund T, Hutchinson K, Leverett D, Marks B, Tyler C.  Environment International (2019): 129. 320-332. Partner: UNEXE (August 2019)

ARTICLE: The Use of Molecular Descriptors To Model Pharmaceutical Uptake by a Fish Primary Gill Cell Culture Epithelium. Chang ED, Hogstrand C, Miller TH, Owen SF, Bury NR. Environ Sci Technol. (2019) 53 (3), 1576-1584. Partner: AZ (February 2019)

ARTICLE: pH‐Dependent Uptake and Sublethal Effects of Antihistamines in Zebrafish (Danio rerio) Embryos. Bittner L, Teixido E, Keddi E, Escher B, Klüver N. Embryos. Environ Toxicol Chem. (2019) 00:1–11. Partner: UFZ (February 2019)

ARTICLE: Prediction of bioconcentration factors in fish and invertebrates using machine learning. Miller TH, Gallidabino MD, MacRae JI, Owen SF, Bury NR, Barron LP. Science of the Total Environment. (2019) 648, 80-89. Partner: AZ (January 2019)

2018

ARTICLE: Machine Learning for Environmental Toxicology: A Call for Integration and Innovation. Miller TH, Gallidabino MD, MacRae JI, Hogstrand C, Bury NR, Barron LP, Snape JR, Owen SF. Environ Sci Technol. (2018) 52 (22), 12953-12955. Partner: AZ (October 2018)

ARTICLE: Development of an Infrastructure for the Prediction of Biological Endpoints in Industrial Environments. Lessons Learned at the eTOX Projects. Pastor M, Quintana J, Sanz F. Front. Pharmacol. (2018) 9:1147. Partner: FIMIM/UPF (October 2018)

ARTICLE: Spheroid size does not impact metabolism of the β-blocker propranolol in 3D intestinal fish model. Langan LM, Owen SF, Trznadel M, Dodd NJF, Jackson SK, Purcell WM, Jha AN. Front. Pharmacol. 2018 9: 947. Partner: AZ (August 2018)

ARTICLE: Influence of pH on the toxicity of β-blockers in embryos of zebrafish,Danio rerio. Bittner L, Teixido E, Seiwert B, Escher B, Klüver N. Aquatic Toxicology. (2018) 201: 129-137. Partner: UFZ (August 2018)

ARTICLE: A review of the pharmaceutical exposome in aquatic fauna. Miller TH, Bury NR, Owen SF, MacRae JI, Barron LP. Environmental Pollution.  (2018) 239, 129-146. Partner: AZ (August 2018).

ARTICLE: Application of prioritization approaches to optimize environmental monitoring and testing of pharmaceuticals.Burns E, Carter L, Snape J, Thomas-Oates J, Boxall A. J Toxicol Env Heal B (2018) 21:3, 115-141 Partner: UoY (May 2018)

ARTICLE: Temporal and spatial variation in pharmaceutical concentrations in an urban river system. Burns E, Carter L, Kolpin D, Thomas-Oates J, Boxall A. Water Research. (2018) 137: 72-85. Partner: UoY (June 2018)

ARTICLE: Establishment and long-term maintenance of primary intestinal epithelial cells cultured from the rainbow trout, Oncorhynchus mykiss. Langan LM, Owen SF, Jha AN. Biology Open (2018) 7(3), bio032870. Partner: AZ (March 2018)

ARTICLE: Assessing the impact of benzo[a]pyrene with the in vitro fish gut model: An integrated approach for eco-genotoxicological studies. Langan LM, Arossa S, Owen SF, Jha AN. Mutation Research/Genetic Toxicology and Environmental Mutagenesis (2018) 826, 53-64. Partner: AZ (February 2018)

ARTICLE: Aqueous-phase photooxygenation of enes, amines, sulfides and polycyclic aromatics by singlet (a1Δg) oxygen: prediction of rate constants using orbital energies, substituent factors and Quantitative Structure-Property. Nolte T, Peijnenburg W. Environ Chem (2018) 14(7) 442-450. Partner: RU (January 2018)

2017

ARTICLE: ECOdrug: a database connecting drugs and conservation of their targets across species. Verbruggen B, Gunnarsson L, Kristiansson E, Österlund T, Owen S, Snape J, Tyler C. Nucleic Acids Research, gkx1024 . Partner: AZ & Exeter University (November 2017)

ARTICLE:  Investigations to extend viability of a rainbow trout primary gill cell culture. Maunder R, Baron M, Owen S, Jha A.  Ecotoxicology (2017) 26: 1314. Partner: AZ (November 2017)

ARTICLE: Application of the rainbow trout derived intestinal cell line (RTgutGC) for ecotoxicological studies: molecular and cellular responses following exposure to copper. Langan L, Harper G, Owen S, Purcell W, Jackson S, Jha A. Ecotoxicology (2017) 26(8): 1117-1133. Partner AZ (October 2017)

ARTICLE: Determination of pharmaceuticals in freshwater sediments using ultrasonic-assisted extraction with SPE clean-up and HPLC-DAD or LC-ESI-MS/MS detection. Al-Khazrajy O, Boxall A. Anal. Methods. 2017;9:4190. Partner: UoY (July 2017)

ARTICLE: Novel Approach for Characterizing pH-Dependent Uptake of Ionizable Chemicals in Aquatic Organisms. Karlsson MV, Carter LJ, Agatz A, Boxall A. Environ. Sci. Technol. 2017;51(12):6965–6971. Partner: UoY (May 2017)

ARTICLE: High Throughput Biodegradation-Screening Test To Prioritize and Evaluate Chemical Biodegradability. Martin T, Goodhead A, Acharya K, Head I, Snape J, Davenport R. Environ. Sci. Technol., 2017, 51 (12), pp 7236–7244  Partner: AZ (May 2017)

ARTICLE:  A Review of Quantitative Structure-Property Relationships for fate of ionizable organic chemicals in water matrices and identification of knowledge gaps. Nolte TM, Ragas AMJ. Environ Sci: Processes Impacts 2017;19(3):221-46. Partner: RU (March 2017)

ARTICLE: General baseline toxicity QSAR for nonpolar, polar and ionisable chemicals and their mixtures in the bioluminescence inhibition assay with Aliivibrio fischeri. Escher BI, Baumer A, Bittermann K, Henneberger L, Konig M, Kühnert C, Klüver N. 2017.  Environmental Science: Processes Impacts. 2017;19:414-28. Partner: UFZ (February 2017)

ARTICLE: Environmentally Relevant Inoculum Concentrations Improve the Reliability of Persistent Assessments in Biodegradation Screening Tests. Environmental Science & Technology. Martin T, Snape J, Bartram A, Robson A, Acharya K, Davenport R. Environ. Sci. Technol., 2017, 51 (5), pp 3065–3073  Partner: AZ (January 2017)

ARTICLE: Pharmaceutical Metabolism in Fish: Using a 3-D Hepatic In Vitro Model to Assess Clearance. Baron MG, Mintram KS, Owen SF, Hetheridge MJ, Moody JA, Purcell WM, Jackson SK, Jha AN. PLoS One. 2017;12(1): e0168837. Partner: AZ (January 2017)

2016

ARTICLE: Development of a general baseline toxicity QSAR model for the fish embryo acute toxicity test. Kluever N, Vogs C, Altenburger R, Escher BI, Scholz S. Chemosphere 2016;164:164-173 Partner: UFZ (Dec. 2016)

ARTICLE: DisGeNET-RDF: Harnessing the Innovative Power of the Semantic Web to Explore the Genetic Basis of Diseases. Queralt-Rosinach N, Piñero J, Bravo A, Sanz F, Furlong LI. Bioinformatics, 2016; 32 (14): 2236-2238. Partner: FIMIM (Jul. 2016)

ARTICLE: Pharmaceuticals in soils of lower income countries: Physico-chemical fate and risks from wastewater irrigation. Lees K, Fitzsimons M, Snape J, Tappin A, Comber S. Environ Int 2016;94:712-23. Partner: AZ (Jun. 2016)

ARTICLE: Combining machine learning, crowdsourcing and expert knowledge to detect chemical-induced diseases in text. Bravo À, Shu-Li T, Su AI, Good BM, Furlong LI. Database (Oxford) 2016: baw094. Partner: FIMIM (Jun. 2016)

ARTICLE: Uncovering disease mechanisms through network biology in the era of Next Generation Sequencing. Piñero J, Berenstein A, Gonzalez-Perez A, Chernomoretz A, Furlong LI. Scientific Reports, 2016; 6: 24570. Parner: FIMIM (Apr. 2016)

ARTICLE: A crowdsourcing workflow for extracting chemical-induced disease relations from free text. Li TS, Bravo A, Furlong LI, Good BM, Su AI. Database (Oxford), 2016; 1-11: baw051. Parner: FIMIM (Mar. 2016)