ECOdrug: a database connecting drugs and conservation of their targets across species
Pharmaceuticals are designed to interact with specific targets in humans and these targets generally have orthologs in other species. This provides opportunities for the drug discovery community to use alternative model species for drug development.
In this context, a new research platform tool has been developed, ECOdrug, that reliably connects drugs to their protein targets across divergent species. ECOdrug can be used to identify species with drug targets and identify drugs that interact with those targets. As such, it can be applied to support intelligent targeted drug safety testing by ensuring appropriate and relevant species are selected in ecological risk assessments.
The collaboration between AstraZeneca and the College of Life & Environmental Sciences at the University of Exeter to understand the environmental risk of medicines has led to this new research platform tool, ECOdrug.
This tool supports industrial, academic and regulatory scientists in assessing and managing the risks associated with pharmaceuticals in the environment. In addition, it represents a new, fantastic first port of call for a new compound to be checked against an existing drug target.
ECOdrug is freely accessible and available at: http://www.ecodrug.org.
More info at the following paper:
Bas Verbruggen, Lina Gunnarsson, Erik Kristansson, Tobias Österlund, Stewart F. Owen, Jason R. Snape and Charles R. Tyler (2017). ECOdrug: a database connecting drugs and conservation of their targets across species. Nucleic Acids Research gkx1024, https://doi.org/10.1093/nar/gkx1024
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